Spotlight on Transformative Technologies & Institutions - one of four AHW Research Priorities

Editor's note: In the third of a series of articles looking at each thematic area of the Alliance’s work, this month we shine the spotlight on our Transformative Technologies and Institutions (TTI) thematic area, led by Dr. Anthony So, and explain how the team's work supports health equity.

Innovation premised on access and co-production in the interests of health equity

In 2015, Gilead Sciences brought to market a life-saving medication called sofosbuvir (brand name: Sovaldi) that cures Hepatitis C. Gilead acquired this medication from another company, Pharmasset, but in so doing, priced the drug at $84,000 for a full course of treatment in the United States. While some parts of the world, notably India, have allowed the production of generics (drugs marketed without patented brand names) thereby reducing the cost of treatment in much of the world, treatment for Hepatitis C remains elusive. A 2018 WHO report showed, of the 71 million people affected by the disease, only about 1.5 million were able to access treatment. 

How do we ensure that the remaining nearly 70 million people receive treatment? How do we reimagine processes of innovation and discovery to bring treatment to those who most need it? How do we ensure that the benefits of health technologies impact populations equitably?

We don’t think it’s enough to drop solutions into inequitable environments without some idea of how they can meaningfully be adopted.
— Dr. Anthony So, Team Lead for AHW Transformative Technologies & Institutions

In order to grapple with these issues, the Alliance for a Healthier World established the Transformative Technologies and Institutions (TTI) thematic area. Dr Anthony So, a veteran in addressing such challenges and a professor of the practice at the Bloomberg School of Public Health, leads this thematic area. 

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  Story illustration and icon for AHW's Transformative Technologies & Institutions thematic priority. © Alliance for a Healthier World

Story illustration and icon for AHW's Transformative Technologies & Institutions thematic priority. © Alliance for a Healthier World

Addressing barriers to access

“We don’t think it’s enough to drop solutions into inequitable environments without some idea of how they can meaningfully be adopted,” Dr. So recently said in announcing the Alliance for a Healthier World’s sponsorship of the health equity prize at this year’s MedHacks 2018 health innovation competition.

Dr. Anthony So of Johns Hopkins Alliance for a Healthier World discusses the health equity track at MedHacks 2018.

This competition – drawing an anticipated 700 MedHack student participants from all over the country – will motivate students to think more deeply about how innovation reaches those in need. This is the first year the competition has a track focused exclusively on health equity.

A focus on health equity means aligning research and development (R&D) efforts with global health priorities, making discoveries affordable to those who need them, and ensuring that innovations physically reach those people. Through such approaches to increasing access, TTI focuses on how to unlock bottlenecks in the R&D pipeline, pioneering new ways of paying for innovations, and shifting how we deliver care to patients in need. 

Open Access and health equity

Library costs worldwide for scientific journals and papers increased significantly between 1986 and 2001, with libraries paying 210% more for 5% fewer periodicals, as noted in a Lancet Commission report on the origins of health inequity. This “paywall” will continue to drive disparities between who can access scientific research and knowledge.

Nearly three quarters of all scholarly literature (research papers, review articles, etc.) is behind a paywall, inaccessible to those who cannot afford to pay the cost of a journal subscription. As an example, a basic search for all cancer articles available at the National Library of Medicine’s PubMed Database, a common repository for biomedical literature, shows that over half of all scholarly articles are behind a paywall.

As one of the world’s leading producers of knowledge, receiving over $2 billion in federal funding for research, Johns Hopkins University’s research output significantly contributes to the global knowledge pool. With the announcement of its open access policy in July 2018, the University is well placed to rapidly expand the public benefit of sharing its research.

In collaboration with the Welch Medical Library, TTI will organize a series of seminars and activities during Open Access Week (October 22-28, 2018) to deepen University-wide understanding of the potential benefits of open access and open science to advance health equity.

Open science to advance health equity

Open access is one part of open science, which includes open methodology, open source technology, open data, open access publishing, open peer review and open educational resources. 

Early in September, the Alliance will sponsor the first-ever health equity track as part of the annual MedHacks health innovation tournament held at the East Baltimore campus of JHU. The theme of the prize is "open science to advance health equity."  The aim is to open new avenues for student innovators to make the the processes of innovation production more accessible and transparent, and easier to share resulting outputs. These improvements would reduce the unequal impact of technology on target populations. 

Anthony So’s commitment to knowledge sharing

  Dr. Anthony So, Lead for AHW's Transformative Technologies & Institutions theme.

Dr. Anthony So, Lead for AHW's Transformative Technologies & Institutions theme.

Dr. So’s commitment to knowledge-sharing in the interest of health equity dates back to his days as the associate director of the health equity division at the Rockefeller Foundation. 

There, he co-founded a cross-thematic program on charting a fairer course for intellectual property rights and helped shape the foundation’s work on policy regarding access to medicines in developing countries. His grant-making efforts supported groups that negotiated the global entry of a generic AIDS triple therapy combination, reducing the cost of treatment $10,000-15,000 per patient per year to just $350--lowering the price of hope to less than a dollar a day.

He has also been part of pioneering efforts to promote open access, co-signing the 2003 Bethesda Open Access Declaration. Together with two other major milestones -- the Budapest Open Access Initiative and the Berlin Declaration on Open Access to Knowledge in the Science -- these interventions have significantly shaped the move toward open access publication of scholarly content. He was also a member of PubMed Central’s Advisory Committee and has served on Open Society Institute’s Information Program Sub-board, as part of his deep commitment and passion to narrow the gap between those who have knowledge and those who need it.

Transforming technology and institutions collectively

More recently, through the Alliance’s planning grants, TTI, together with three other AHW thematic areas (Food & nutrition security, Healthy environments, Gender equity & justice), supported a project that typifies the Alliance’s multidisciplinary approach to innovation for health equity. 

A team of researchers drawn from across the University -- from the Carey Business School, Krieger School of Arts & Sciences, Whiting School of Engineering, and Bloomberg School of Public Health -- joined forces to tackle the persistent problem of household air pollution caused by cooking with biomass fuel in Puno, a rural region of Peru. The wider problem of household air pollution is thought to contribute to 4.3 million premature deaths annually, disproportionately affecting women and children. 

The multi-disciplinary Hopkins team, drawing on locally available materials, proposes "thermal cooking" as a solution. Their innovation involves using a new type of cook stove that uses liquid petroleum gas (LPG) instead of biomass fuel to heat the food for a short time at high temperature, before enclosing the pot in a heavily insulated container. This would cook the food, maintaining temperature for several hours, without releasing smoke. 

If successful, this innovation would free biomass for alternative uses, thus saving money, and make available biomass as fertilizer for more nutritious crops. By using LPG, the cook stove reduces harmful agents emitted into households and external environments. It also reduces the effect of toxins released into the household, particularly on women and children, who disproportionately bear the consequences of biomass fuel use, as they spend up to six hours per day around a stove. By employing locally available materials, ensuring that the final cost of the stove would be affordable by those who would need to use it, and by serving a need with an identifiable benefit to the community, this proposed invention is truly transformative.

The project exemplifies an Alliance-wide approach to achieving health equity by combining the collective approaches we bring to tackling public health challenges and striving for a healthier and more equitable world.

Further Resources

Author Acknowledgement

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This spotlight profile was written by Vinayak Bhardwaj, a Global Health Equity Scholar with the Alliance for a Healthier World.